Protein Details: 5-hydroxytryptamine receptor 3C

Protein ID

ICDB_Pro_1344

Protein Name

5-hydroxytryptamine receptor 3C

Gene Name

HTR3C

Organism

Homo sapiens (Human)

Length

447 amino acids

AlphaFoldDB

AF-Q8WXA8-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes;which when activated cause fast;depolarizing responses in neurons.

Sequence

MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Currarino Syndrome

Location

Expressed in many tissues including adult brain;colon;intestine;lung;muscle and stomach as well as fetal colon and kidney

DOI ID

10.1016/s0378-1119(03)00503-1; 10.1101/gr.2596504; 10.1124/mol.106.032144; 10.1126/science.1133427

RefSeq

NP_570126.2